This issue brief has been prepared by the African Institute for Development Policy (AFIDEP) based on the study, “Sustained reduction in third-generation cephalosporin usage in adult inpatients following introduction of an antimicrobial stewardship program in a large urban hospital in Malawi (https://pubmed.ncbi.nlm.nih.gov/32060523/). The work was led by Rebecca Lester and supported by the Drivers of Resistance in Uganda and Malawi (DRUM) Consortium. The study sought to demonstrate the feasibility, acceptability and cost-saving of a stewardship program where resources are limited. With funding from the UK Global Challenges Research Fund, the Liverpool School of Tropical Medicine (LSTM) in 2017 established the DRUM Consortium with the purpose of reducing antimicrobial resistance (AMR) spread in Uganda and Malawi. This issue brief seeks to promote and support the continued investment in antimicrobial resistance solutions.