


This issue brief has been prepared by the African Institute for Development Policy (AFIDEP) based on the study, “Sustained reduction in third-generation cephalosporin usage in adult inpatients following introduction of an antimicrobial stewardship program in a large urban hospital in Malawi (https://pubmed.ncbi.nlm.nih.gov/32060523/). The work was led by Rebecca Lester and supported by the Drivers of Resistance in Uganda and Malawi (DRUM) Consortium. The study sought to demonstrate the feasibility, acceptability and cost-saving of a stewardship program where resources are limited. With funding from the UK Global Challenges Research Fund, the Liverpool School of Tropical Medicine (LSTM) in 2017 established the DRUM Consortium with the purpose of reducing antimicrobial resistance (AMR) spread in Uganda and Malawi. This issue brief seeks to promote and support the continued investment in antimicrobial resistance solutions.
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While notable progress has been made in Malawi’s efforts to meet the Millennium Development Goals surrounding child health and child survival, progress in curbing neonatal and maternal mortality and morbidity has been less substantial. The rate of progress has been less than half of that for overall child mortality, with neonatal deaths at 22 per thousand live births in 2018. Neonatal disorders come second only to HIV/AIDS in terms of years lost due to ill-health, disability or early death.
Cost-Benefit Analysis run against the most promising singular and sets of interventions within Malawi’s environment revealed two interventions with significant promise.

In this report, we have assessed the costs and benefits of delivering improved emergency obstetric and newborn care (EmONC) and nutritional supplements. Our analysis shows that many of these interventions have benefit-cost ratios (BCRs) of greater than 15 and could be very good uses of resources to improve maternal and neonatal health in Malawi.
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